HORDB

ID: hor005888
Uniprot ID: Q9GM96
Protein name: Neuropeptide RFRP-3
Gene name: NPVF
Organism: Bos taurus (Bovine)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032277 negative regulation of gonadotropin secretion
GO CC: GO:0005576 extracellular region

Sequence: WVPNLPQRF
Length: 9
Propeptide: MEIISLKRFILLMLATSSLLTSNIFCTDESRMPNLYSKKNYDKYSEPRGDLGWEKERSLTFEEVKDWAPKIKMNKPVVNKMPPSAANLPLRFGRNMEEERSTRAMAHLPLRLGKNREDSLSRWVPNLPQRFGRTTTAKSITKTLSNLLQQSMHSPSTNGLLYSMACQPQEIQNPGQKNLRRRGFQKIDDAELKQEK
Signal peptide: MEIISLKRFILLMLATSSLLT
Modification: T9 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptide NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005888_AF2.pdb

hor005888_ESM.pdb

Mass:	129922	Formula:	C56H81N15O12
Absent amino acids:	ACDEGHIKMSTY	Common amino acids:	P
pI:	10.55	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	4
Hydrophobicity:	-53.33	Boman Index:	-1283
Half-Life:	2.8 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	75.56
Instability Index:	6365.56	Extinction Coefficient cystines:	5500
Absorbance 280nm:	687.5

PubMed ID: 11025660
Title: New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
PubMed ID: 11583817
Title: Characteristics and distribution of endogenous RFamide-related peptide-1.